(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol

Base Information

Chemical Name:(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol
CAS No.:952652-10-7
Molecular Formula:C₂₇H₃₂O₃Si
Molecular Weight:432.635
Hs Code.:

Synonyms:(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol

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Technology Process of (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol

There total 10 articles about (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 952652-05-0
(-)-(R)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane

: 497-06-3,86161-40-2
3,4-butenediol

: 952652-10-7
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol

Guidance literature:: (-)-(R)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane; With bromine; In dichloromethane; at -78 ℃;

3,4-butenediol; With dmap; triethylamine; In dichloromethane; at 0 - 23 ℃; for 1h; Further stages.;
DOI:10.1021/ol071382h

Reference yield:

: 952652-08-3
(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propan-1-ol

: 952652-10-7
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 23 °C

2.1: MgBr₂ / CH₂Cl₂; diethyl ether / 0.33 h / -78 °C

3.1: 96 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

4.1: Br₂ / CH₂Cl₂ / -78 °C

4.2: 92 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

With lithium aluminium tetrahydride; oxalyl dichloride; bromine; dimethyl sulfoxide; triethylamine; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Swern oxidation;
DOI:10.1021/ol071382h

Reference yield:

: 952651-74-0
(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

: 952652-10-7
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]but-3-en-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: MgBr₂ / CH₂Cl₂; diethyl ether / 0.33 h / -78 °C

2.1: 96 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

3.1: Br₂ / CH₂Cl₂ / -78 °C

3.2: 92 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

With lithium aluminium tetrahydride; bromine; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol071382h