(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

Base Information

Chemical Name:(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde
CAS No.:952651-74-0
Molecular Formula:C₂₆H₃₀O₃Si
Molecular Weight:418.608
Hs Code.:

Synonyms:(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

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Chemical Property of (1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

Chemical Property:

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Technology Process of (1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

There total 8 articles about (1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 952652-08-3
(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propan-1-ol

: 952651-74-0
(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 23 ℃;
DOI:10.1021/ol071382h

Reference yield:

: 952652-05-0
(-)-(R)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane

: 952651-74-0
(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: Br₂ / CH₂Cl₂ / -78 °C

1.2: 96 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

2.1: 96 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 23 °C

With oxalyl dichloride; bromine; dimethyl sulfoxide; triethylamine; In dichloromethane; 2.1: Swern oxidation;
DOI:10.1021/ol071382h

Reference yield:

: 952651-71-7
(+/-)-(1-methoxy-2,2,2-triphenylethyl)(phenyl)dimethylsilane

: 952651-74-0
(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: Fe; Br₂ / 1,2-dichloro-ethane / 1.5 h / -10 °C

1.2: 98 percent / LiAlH₄ / 1,2-dichloro-ethane; diethyl ether / 3 h / 0 - 23 °C

2.1: Br₂ / CH₂Cl₂ / -78 - 23 °C

2.2: 38 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

3.1: LiAlH₄ / CH₂Cl₂; diethyl ether / 1 h / 0 - 23 °C

4.1: Br₂ / CH₂Cl₂ / -78 °C

4.2: 96 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

5.1: 96 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 23 °C

With lithium aluminium tetrahydride; oxalyl dichloride; bromine; iron; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; 1,2-dichloro-ethane; 5.1: Swern oxidation;
DOI:10.1021/ol071382h