Technology Process of (+)-5-{[(3S,4R)-4-[(3,4-dimethoxyphenyl)methyl]tetrahydro-3-furanyl]methyl}-1,3-benzodioxole
There total 9 articles about (+)-5-{[(3S,4R)-4-[(3,4-dimethoxyphenyl)methyl]tetrahydro-3-furanyl]methyl}-1,3-benzodioxole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; p-toluenesulfonyl chloride;
In
dichloromethane;
at 20 ℃;
for 24h;
DOI:10.2298/JSC090410108X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ethanol / 1 h / Reflux
2: sulfuric acid / benzene / 36 h / Reflux
3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h
4: lithium aluminium tetrahydride / tetrahydrofuran / 10 h
5: pyridine; p-toluenesulfonyl chloride / dichloromethane / 24 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; sulfuric acid; palladium 10% on activated carbon; hydrogen; p-toluenesulfonyl chloride;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; benzene;
DOI:10.2298/JSC090410108X
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 10 h
2: pyridine; p-toluenesulfonyl chloride / dichloromethane / 24 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; p-toluenesulfonyl chloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.2298/JSC090410108X
