Technology Process of diethyl 2-(3,4-dimethoxybenzylidene)-3-(3,4-methylenedioxybenzyl)succinate
There total 2 articles about diethyl 2-(3,4-dimethoxybenzylidene)-3-(3,4-methylenedioxybenzyl)succinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl 2-(3,4-dimethoxybenzylidene)succinate;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
3,4-Methylenedioxybenzyl bromide;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
Inert atmosphere;
DOI:10.2298/JSC090410108X
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium ethanolate / ethanol / 4 h / Reflux
1.2: 24 h / Reflux
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
With
sodium ethanolate; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol;
DOI:10.2298/JSC090410108X
- Guidance literature:
-
Multi-step reaction with 6 steps
1: water; sodium hydroxide / 3 h / Reflux
2: ethanol / 1 h / Reflux
3: sulfuric acid / benzene / 36 h / Reflux
4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h
5: lithium aluminium tetrahydride / tetrahydrofuran / 10 h
6: pyridine; p-toluenesulfonyl chloride / dichloromethane / 24 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; p-toluenesulfonyl chloride; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; benzene;
DOI:10.2298/JSC090410108X
