1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide

Base Information

Chemical Name:1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide
CAS No.:915192-38-0
Molecular Formula:C₂₃H₁₇F₆N₃O₆S
Molecular Weight:577.461
Hs Code.:

Synonyms:1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide

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Chemical Property of 1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide

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Technology Process of 1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide

There total 6 articles about 1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915192-30-2
1-(4-amino-3-methylphenyl)methanesulfonamide

: 915192-37-9
5,9-bis(2,2,2-trifluoroethoxy)furo[3,4-g]quinoline-6,8-dione

: 915192-38-0
1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide

Guidance literature:: 1-(4-amino-3-methylphenyl)methanesulfonamide; 5,9-bis(2,2,2-trifluoroethoxy)furo[3,4-g]quinoline-6,8-dione; With trifluoroacetic acid; In tetrahydrofuran; at 16 - 67 ℃; for 11.4167h; Inert atmosphere; Large scale reaction;

With n-heptane; In tetrahydrofuran; at 67 ℃; for 0.5h; Inert atmosphere; Large scale reaction;
DOI:10.1021/jo901267x

Reference yield:

: 915192-31-3
1-(3-methyl-4-nitrophenyl)methanesulfonamide

: 915192-38-0
1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol; acetic acid / 3 h / 2068.65 Torr

2: acetic acid / 6.5 h / Heating / reflux

With hydrogen; palladium 10% on activated carbon; In ethanol; acetic acid;

Reference yield:

: 141281-38-1
4-(bromomethyl)-2-methyl-1-nitrobenzene

: 915192-38-0
1-{4-[6,8-dioxo-5,9-bis(2,2,2-trifluoroethoxy)-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl]-3-methylphenyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium 3-sulfonatopropionic acid methylester / dimethyl sulfoxide / 3 h / 20 - 28 °C

1.2: -10 - 0 °C

1.3: 0 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; acetic acid / 3 h / 2068.65 Torr

3.1: acetic acid / 6.5 h / Heating / reflux

With sodium 3-sulfonatopropionic acid methylester; hydrogen; palladium 10% on activated carbon; In ethanol; acetic acid; dimethyl sulfoxide;