N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide
CAS No.:1428766-66-8
Molecular Formula:C₁₄H₂₁BrN₂O₂S
Molecular Weight:361.303
Hs Code.:

Synonyms:N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide

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Chemical Property of N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide

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Technology Process of N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide

There total 7 articles about N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1428766-62-4
[2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-isopropylamine

: 1428766-66-8
N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h; Reflux;
DOI:10.1016/j.tet.2013.02.065

Reference yield:

: 1428766-57-7
ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

: 1428766-66-8
N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2: bromine / dichloromethane / 24 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 2 h / 60 °C

4: lithium aluminium tetrahydride / diethyl ether / 1 h / -78 °C

5: magnesium sulfate / dichloromethane / 2 h / Reflux

6: sodium tetrahydroborate / methanol / 2 h / 0 °C / Reflux

With sodium tetrahydroborate; lithium aluminium tetrahydride; bromine; magnesium sulfate; potassium carbonate; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.02.065

Reference yield:

: 1092540-02-7
ethyl 2-{[(4-methylbenzene)sulfonamido]methyl}acrylate

: 1428766-66-8
N-(2-bromomethyl-1-isopropylaziridin-2-ylmethyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / dichloromethane / 24 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 2 h / 60 °C

3: lithium aluminium tetrahydride / diethyl ether / 1 h / -78 °C

4: magnesium sulfate / dichloromethane / 2 h / Reflux

5: sodium tetrahydroborate / methanol / 2 h / 0 °C / Reflux

With sodium tetrahydroborate; lithium aluminium tetrahydride; bromine; magnesium sulfate; potassium carbonate; In methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.02.065