ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

Base Information

Chemical Name:ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate
CAS No.:1428766-57-7
Molecular Formula:C₁₈H₂₅NO₆S
Molecular Weight:383.466
Hs Code.:

Synonyms:ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

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Chemical Property of ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

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Technology Process of ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

There total 1 articles about ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 10029-04-6
ethyl 2-(hydroxymethyl)acrylate

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 1428766-57-7
ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.tet.2013.02.065

Reference yield: 98.0%

: 1428766-57-7
ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

: 1092540-02-7
ethyl 2-{[(4-methylbenzene)sulfonamido]methyl}acrylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.tet.2013.02.065

Reference yield:

: 1428766-57-7
ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

: 1428766-64-6
N-[1-benzyl-2-(bromomethyl)aziridin-2-ylmethyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 24 h / 0 - 20 °C

3.1: potassium carbonate / acetonitrile / 2 h / 60 °C

4.1: lithium aluminium tetrahydride / diethyl ether / 1 h / -78 °C

5.1: acetic acid / methanol / 4 h / 50 °C

5.2: 15 h / Reflux

With lithium aluminium tetrahydride; bromine; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.02.065