tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate

Base Information

• Chemical Name: tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate
• CAS No.: 159826-53-6
• Molecular Formula: C₂₅H₃₆O₂S
• Molecular Weight: 400.626
• Mol file: 159826-53-6.mol

Synonyms:tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate

Chemical Property of tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate

There total 5 articles about tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-nerylacetone (3879-26-3) → tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate (159826-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) LDA / 1) THF, hexane, 45 deg C, 1 h, 2) HMPA, -2 to 0 deg C, 1 h

2: 1) LDA / 1) THF, hexane, -70 deg C, 2 h, 2) -70 deg C, 2 h

With lithium diisopropyl amide;

DOI:10.1007/BF00702395

Reference yield:

diphenyldisulfane (882-33-7) → tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate (159826-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) LDA / 1) THF, hexane, 45 deg C, 1 h, 2) HMPA, -2 to 0 deg C, 1 h

2: 1) LDA / 1) THF, hexane, -70 deg C, 2 h, 2) -70 deg C, 2 h

With lithium diisopropyl amide;

DOI:10.1007/BF00702395

Reference yield:

tert-butyl (trimethylsilyl)acetate (41108-81-0) + 6,10-dimethyl-3-phenylthioundeca-5Z,9-dien-2-one (159826-46-7) → tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trienoate (159826-53-6) + tert-butyl 3,7,11-trimethyl-4-(phenylthio)dodeca-2E,6Z,10-trienoate (159826-54-7)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, hexane, -70 deg C, 2 h, 2) -70 deg C, 2 h;

DOI:10.1007/BF00702395

upstream raw materials:

tert-butyl (trimethylsilyl)acetate

6,10-dimethyl-3-phenylthioundeca-5Z,9-dien-2-one

tert-butyl α-(dimethylphenylsilyl)acetate

(Z)-nerylacetone

Downstream raw materials:

3,7,11-trimethyl-4-(phenylthio)dodeca-2Z,6Z,10-trien-1-ol

(2Z,6Z)-farnesol