tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Base Information

Chemical Name:tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate
CAS No.:1363479-76-8
Molecular Formula:C₂₆H₂₅N₃O₇S
Molecular Weight:523.566
Hs Code.:

Synonyms:tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

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Chemical Property of tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

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Technology Process of tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

There total 17 articles about tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1363479-74-6
tert-butyl 7-cyano-1-(hydroxymethyl)-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

: 1939-99-7
benzenesulfonyl chloride

: 1363479-76-8
tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 6h;
DOI:10.1021/jm201717y

Reference yield:

: C₁₄H₁₁IN₂

: 1363479-76-8
tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 2 h / 0 °C

2.1: acetic acid / 48 h / Reflux

3.1: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

4.1: caesium carbonate / tetrahydrofuran; water / 2 h / Reflux

4.2: 3 h / Reflux

5.1: tetrahydrofuran / 24 h / Inert atmosphere; Reflux

6.1: pyridine / dichloromethane / 6 h / 0 - 20 °C

With pyridine; sulfuric acid; caesium carbonate; potassium nitrate; In tetrahydrofuran; dichloromethane; water; acetic acid;
DOI:10.1021/jm201717y

Reference yield:

: 1363479-55-3
tert-butyl 1-(acetoxymethyl)-7-cyano-1H-benzo[e]indole-3(2H)-carboxylate

: 1363479-76-8
tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2.1: pyridine / 4 h / 0 °C

3.1: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

4.1: caesium carbonate / tetrahydrofuran; water / 2 h / Reflux

4.2: 3 h / Reflux

5.1: tetrahydrofuran / 24 h / Inert atmosphere; Reflux

6.1: pyridine / dichloromethane / 6 h / 0 - 20 °C

With pyridine; sulfuric acid; caesium carbonate; potassium nitrate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201717y