(7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Base Information

Chemical Name:(7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
CAS No.:1363479-78-0
Molecular Formula:C₂₁H₁₇N₃O₅S
Molecular Weight:423.449
Hs Code.:

Synonyms:(7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Chemical Property:

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Technology Process of (7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

There total 19 articles about (7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1363479-76-8
tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-cyano-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

: 1363479-78-0
(7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm201717y

Reference yield:

: C₁₄H₁₁IN₂

: 1363479-78-0
(7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 2 h / 0 °C

2.1: acetic acid / 48 h / Reflux

3.1: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

4.1: caesium carbonate / tetrahydrofuran; water / 2 h / Reflux

4.2: 3 h / Reflux

5.1: tetrahydrofuran / 24 h / Inert atmosphere; Reflux

6.1: pyridine / dichloromethane / 6 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; sulfuric acid; caesium carbonate; potassium nitrate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetic acid;
DOI:10.1021/jm201717y

Reference yield:

: 1363479-64-4
tert-butyl 7-cyano-1-(hydroxymethyl)-1H-benzo[e]indole-3(2H)-carboxylate

: 1363479-78-0
(7-cyano-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; triethylamine / tetrahydrofuran / 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.1: pyridine / 4 h / 0 °C

4.1: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

5.1: caesium carbonate / tetrahydrofuran; water / 2 h / Reflux

5.2: 3 h / Reflux

6.1: tetrahydrofuran / 24 h / Inert atmosphere; Reflux

7.1: pyridine / dichloromethane / 6 h / 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; dmap; sulfuric acid; caesium carbonate; potassium nitrate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201717y