5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621705-20-1
Molecular Formula:C₃₅H₃₀F₂N₄O₄S
Molecular Weight:640.71
Hs Code.:

5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 6 articles about 5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1621706-33-9
5-(6-(4-fluoro-1H-indol-2-yl)-5-(4-hydroxybutyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 1621705-20-1
5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; at 50 ℃; for 16h;

Reference yield:

: 148493-37-2
2,6-dichloro-3-iodo-pyridine

: 1621705-20-1
5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water / 16 h / 20 °C

2: hydrogen; 10% Pt/activated carbon / methanol / 2 h

3: caesium carbonate; XPhos / water; 1,4-dioxane / 16 h / 70 °C

4: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 18 h / 70 °C / Inert atmosphere

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 50 °C

With potassium phosphate; di-isopropyl azodicarboxylate; 10% Pt/activated carbon; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); hydrogen; caesium carbonate; triphenylphosphine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 1621706-31-7
(E)-3-(4-((tert-butyldimethylsilyl)oxy)but-1-en-1-yl)-2,6-dichloropyridine

: 1621705-20-1
5-(13-fluoro-5,6,7,8-tetrahydropyrido[2’,3‘:3,4]azocino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; 10% Pt/activated carbon / methanol / 2 h

2: caesium carbonate; XPhos / water; 1,4-dioxane / 16 h / 70 °C

3: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 18 h / 70 °C / Inert atmosphere

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 50 °C

With di-isopropyl azodicarboxylate; 10% Pt/activated carbon; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); hydrogen; caesium carbonate; triphenylphosphine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water;