6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

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Chemical Name:6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine
CAS No.:1443750-32-0
Molecular Formula:C₁₇H₁₁ClF₃N₅
Molecular Weight:377.756
Hs Code.:

Synonyms:6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

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Chemical Property of 6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

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Technology Process of 6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

There total 3 articles about 6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 344591-91-9
[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid

: 1443750-41-1
2-bromo-6-(2-chloro-phenyl)-5H-pyrrolo[2,3-b]pyrazine

: 1443750-32-0
6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 18h;

Reference yield:

: 1443750-40-0
5-bromo-3-(2-chloro-phenylethynyl)-pyrazin-2-ylamine

: 1443750-32-0
6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / 2.5 h / 75 °C

2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 18 h / 110 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium tert-butylate; potassium carbonate; In 1,4-dioxane; water; 2: |Suzuki Coupling;

Reference yield:

: 873-31-4
2-chlorophenylacetylene

: 1443750-32-0
6-(2-chloro-phenyl)-2-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2: potassium tert-butylate / 2.5 h / 75 °C

3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 18 h / 110 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium tert-butylate; potassium carbonate; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling / 3: |Suzuki Coupling;