(4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester

Base Information

Chemical Name:(4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester
CAS No.:187157-76-2
Molecular Formula:C₃₃H₂₉ClN₂O₄
Molecular Weight:553.057
Hs Code.:

Synonyms:(4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester

There total 6 articles about (4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 187157-74-0
(4S,5S)-1-benzyl-5-(2^IV-chloroacetyl)-2-oxo-3-(9''-phenylfluoren-9''-yl)imidazolidine-4-carboxylic acid methyl ester

: 187157-76-2
(4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester

: (4S,5S)-1-Benzyl-5-((R)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/jo970277q

Reference yield:

: 159434-59-0
dimethyl (2S,3S)-2-azido-3-(9-phenyl-9H-fluoren-9-ylamino)succinate

: 187157-76-2
(4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) H₂, 2.) Na₂CO₃ / 1.) Pd/BaCO₃ / 1.) MeOH, 1 atm, 3 h, 2.) CH₂Cl₂, H₂O, reflux, 54 h

2: 83 percent / DMAP / pyridine / 0.33 h / 70 °C

3: 100 percent / MeLi, LiBr / tetrahydrofuran; diethyl ether / 1.25 h / -78 °C

4: DIBAL-H / CH₂Cl₂; hexane / 1.17 h / -78 °C

With dmap; methyllithium; hydrogen; diisobutylaluminium hydride; sodium carbonate; lithium bromide; palladium-barium carbonate; In tetrahydrofuran; pyridine; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo970277q

Reference yield:

: 100-39-0
benzyl bromide

: 187157-76-2
(4S,5S)-1-Benzyl-5-((S)-2-chloro-1-hydroxy-ethyl)-2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-imidazolidine-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) H₂, 2.) Na₂CO₃ / 1.) Pd/BaCO₃ / 1.) MeOH, 1 atm, 3 h, 2.) CH₂Cl₂, H₂O, reflux, 54 h

2: 83 percent / DMAP / pyridine / 0.33 h / 70 °C

3: 100 percent / MeLi, LiBr / tetrahydrofuran; diethyl ether / 1.25 h / -78 °C

4: DIBAL-H / CH₂Cl₂; hexane / 1.17 h / -78 °C

With dmap; methyllithium; hydrogen; diisobutylaluminium hydride; sodium carbonate; lithium bromide; palladium-barium carbonate; In tetrahydrofuran; pyridine; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo970277q