Multi-step reaction with 5 steps
1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; methanol / 48 h / Reflux; Inert atmosphere
2: platinum(IV) oxide; acetic acid; hydrogen / 9 h / 20 °C / 2250.23 Torr
3: tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate / 1,4-dioxane; acetonitrile / 15 h / 50 - 55 °C / Inert atmosphere
4: hydrogenchloride / isopropyl alcohol / 4 h / 20 °C
5: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 12 h / 20 °C
With
hydrogenchloride; platinum(IV) oxide; tris-(dibenzylideneacetone)dipalladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; hydrogen; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; johnphos; sodium t-butanolate;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;