(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

Base Information

Chemical Name:(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride
CAS No.:1444780-57-7
Molecular Formula:C₂₁H₂₈N₂O*ClH
Molecular Weight:360.927
Hs Code.:

Synonyms:(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

Chemical Property:

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Technology Process of (S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

There total 6 articles about (S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 699-08-1
1-ethoxy-4-iodobenzene

: 1444780-57-7
(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; methanol / 48 h / Reflux; Inert atmosphere

2: platinum(IV) oxide; acetic acid; hydrogen / 9 h / 20 °C / 2250.23 Torr

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane; acetonitrile / 15 h / 50 - 55 °C / Inert atmosphere

4: hydrogenchloride / isopropyl alcohol / 4 h / 20 °C

With hydrogenchloride; platinum(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; sodium carbonate; acetic acid; johnphos; sodium t-butanolate; In 1,4-dioxane; methanol; isopropyl alcohol; acetonitrile;

Reference yield:

: C₂₆H₃₆N₂O₃

: 1444780-57-7
(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 4h;

Reference yield:

: 847728-89-6
(S)-tert-butyl (1-(4-bromophenyl)ethyl)carbamate

: 760150-51-4
4-(4-ethoxy-phenyl)-piperidine

: 1444780-57-7
(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium butyrate; johnphos; In 1,4-dioxane; at 50 - 55 ℃; for 15h; Inert atmosphere;