5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole

Base Information

• Chemical Name: 5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole
• CAS No.: 268549-39-9
• Molecular Formula: C₂₈H₂₄Cl₂N₂O₅
• Molecular Weight: 539.415
• Mol file: 268549-39-9.mol

Synonyms:5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole

Chemical Property of 5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole

There total 3 articles about 5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5,6-dichlorobenzimidazole (6478-73-5) + 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) → 5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole (268549-39-9)

Guidance literature:

5,6-dichlorobenzimidazole; With sodium hydride; In acetonitrile; at 0 - 20 ℃; for 1h;

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride; In acetonitrile; at 0 - 20 ℃; for 2h;

Reference yield:

5,6-dichlorobenzimidazole (6478-73-5) + 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride (3056-12-0,3601-89-6,4330-21-6,52304-86-6,141846-57-3) → 5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole (268549-39-9)

Guidance literature:

5,6-dichlorobenzimidazole; With sodium hydride; In acetonitrile; for 0.166667h; Reflux;

2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride; In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1016/j.ejphar.2017.12.018

Reference yield:

Hoffer's chlorosugar (3601-89-6,4330-21-6,52304-86-6,3056-12-0,141846-57-3) + 5,6-dichlorobenzimidazole (6478-73-5) → 5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole (268549-39-9)

Guidance literature:

DOI:10.1080/15257770008033000

upstream raw materials:

Hoffer's chlorosugar

5,6-dichlorobenzimidazole

2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride