17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, (2E,5alpha,17beta)-

Base Information Edit

Chemical Name:17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, (2E,5alpha,17beta)-
CAS No.:434-07-1
Molecular Formula:C21H32O3
Molecular Weight:332.483
Hs Code.:29372900
European Community (EC) Number:207-098-6
UNII:77LW93C64T
Wikipedia:Oxymetholone
Metabolomics Workbench ID:198496
ChEMBL ID:CHEMBL4303342
Mol file:434-07-1.mol

Synonyms:UNII-77LW93C64T;77LW93C64T;156197-08-9;434-07-1;17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, (2E,5alpha,17beta)-;Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17-methyl-, (2E,5alpha,17beta)-;SMR000058877;Oxymetholone [USAN:BAN:INN:JAN];NSC 26198;MLS000759530;MLS001424048;CHEMBL4303342;(5-alpha,17-beta)-17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one;Androstan-3-ona, 17-hidroxi-2-(hidroximetileno)-17-metil-, (5alfa,17beta )-;Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17-methyl-, (5.alpha.,17.beta.)-;HMS2051H15;HMS3715N20;AKOS015962213;CCG-100962;CCG-221269;NC00212;AC-16143;Q27266591;(2E,5alpha,17beta)-17-hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one;17-HYDROXY-2-(HYDROXYMETHYLENE)-17-METHYLANDROSTAN-3-ONE, (2E,5.ALPHA.,17.BETA.)-;ANDROSTAN-3-ONE, 17-HYDROXY-2-(HYDROXYMETHYLENE)-17-METHYL-, (2E,5.ALPHA.,17.BETA.)-

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Chemical Property of 17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, (2E,5alpha,17beta)- Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:1.23E-10mmHg at 25°C
Melting Point:172-180 °C
Refractive Index:38 ° (C=1, CHCl3)
Boiling Point:465.9 °C at 760 mmHg
PKA:5.28±0.70(Predicted)
Flash Point:249.7 °C
PSA：57.53000
Density:1.169 g/cm³
LogP:4.40100
Storage Temp.:2-8°C
Solubility.:H2O: ≤0.5 mg/mL
Water Solubility.:<0.1 g/100 mL at 23℃
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:332.23514488
Heavy Atom Count:24
Complexity:596

Purity/Quality:

Safty Information:

Pictogram(s): T, Xn
Hazard Codes:T,Xn
Statements: 40-63
Safety Statements: 53-22-26-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC12CCC3C(C1CCC2(C)O)CCC4C3(CC(=CO)C(=O)C4)C
Isomeric SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(C/C(=C\O)/C(=O)C4)C
description Oxymetholone is an orally active synthetic anabolic steroid and a 17alpha-methylated derivative of dihydrotestosterone, with androgenic activity. Although oxymetholone has low affinity for binding the androgen receptor (AR), it strongly activates AR-mediated signaling, which stimulates both protein synthesis and erythropoietin production. This agent may stimulate muscle growth, induce hemoglobin production and red blood cell formation, and promote increased bone density.
Description Oxymetholone is a synthetic, orally active anabolic-androgenic steroid (AAS) and 17α-methylated derivative of dihydrotestosterone (DHT). It is mainly used for the treatment of osteroporosis and anemia (low red blood cell count). It can also stimulate the muscle growth in malnourished or underdeveloped patients. It also has the potential to treat the HIV wasting syndrome. Oxymetholone can also lead to an even buildup in strength, which is its secondary characteristics, making it an excellent steroid to be coupled with other anabolic steroids to yield synergetic effect.
Uses Oxymetholone is used in treatment of myelofibrosis and myelosuppression. This drug can provoke bone marrow cells and rise the blood cells in the peripheral blood vessels. It has been approved by the US Food and Drug Administration for the treatment of anemia caused by deficient red cell production. It is effective in catabolic states, replacement of male sex steroids in men who have androgen deficiency, and in eugonadal male and female patients with acquired immunodeficiency syndrome-associated wasting.

Technology Process of 17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, (2E,5alpha,17beta)-

There total 6 articles about 17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, (2E,5alpha,17beta)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: