methyl 4-azido-2,3,5,6-tetrafluorobenzoate

Base Information

• Chemical Name: methyl 4-azido-2,3,5,6-tetrafluorobenzoate
• CAS No.: 122590-75-4
• Molecular Formula: C8H3 F4 N3 O2
• Molecular Weight: 249.124
• Mol file: 122590-75-4.mol

Synonyms:Methyl4-azido-2,3,5,6-tetrafluorobenzoate; Methyl 4-azidotetrafluorobenzoate

Chemical Property of methyl 4-azido-2,3,5,6-tetrafluorobenzoate

Chemical Property:

• Melting Point: 54-55°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 76.05000
• Density: g/cm³
• LogP: 2.42416
• Storage Temp.: Refrigerator

Purity/Quality:

98% ^*data from raw suppliers

Methyl4-Azidotetrafluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A protected photoaffinity reagent.

Technology Process of methyl 4-azido-2,3,5,6-tetrafluorobenzoate

There total 5 articles about methyl 4-azido-2,3,5,6-tetrafluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl pentafluorobenzoate (36629-42-2) → methyl 4-azidotetrafluorobenzoate (122590-75-4)

Guidance literature:

With sodium azide; In water; acetone; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.1c09229

Reference yield: 96.0%

methyl 4-amino-2,3,5,6-tetrafluorobenzoate (715-37-7) → methyl 4-azidotetrafluorobenzoate (122590-75-4)

Guidance literature:

With sodium azide; trifluoroacetic acid; sodium nitrite; at 0 ℃; for 2.66667h;

DOI:10.1021/j100053a012

Reference yield: 60.0%

methyl pentafluorobenzoate (36629-42-2) → methyl 2-azido-3,4,5,6-tetrafluorobenzoate + methyl 4-azidotetrafluorobenzoate (122590-75-4)

Guidance literature:

With sodium azide; In water; acetone; at 70 ℃; for 0.25h; Reflux; Microwave irradiation;

DOI:10.1016/j.jfluchem.2013.10.002

upstream raw materials:

methyl pentafluorobenzoate

methyl 4-amino-2,3,5,6-tetrafluorobenzoate

Pentafluorobenzoic acid

dimethyl 2,3,5,6-tetrafluoroterephthalate

Downstream raw materials:

methyl 4-amino-2,3,5,6-tetrafluorobenzoate

2,2,3,3-tetramethyl-1-(2,3,5,6-tetrafluoro-4-carbomethoxyphenyl)aziridine

methyl 2-(2-aminoethyl)amino-4-azido-3,5,6-trifluorobenzoate

3-[2-(4-azido-2,3,5-trifluoro-6-methylamino-benzoylamino)-ethyldisulfanyl]-propionic acid