36629-42-2Relevant articles and documents
Study of Pd-elimination under carbonylation conditions: Regioselective formation of esters
Albeniz, Ana C.,Espinet, Pablo,Lin, Yong-Shou
, p. 13851 - 13866 (1998)
The regioselective synthesis of methyl esters is achieved by carbonylation of two different types of organometallic derivatives resulting from insertion of non-conjugated dienes into a Pd-aryl bond. When the diene and the Pd-aryl synthon [PdPfBr(NCMe)2] (Pf = C6F5) are mixed at low temperature, solutions of η1-η2-enylpalladium complexes can be isolated and converted into β-aryl methyl esters by reaction with CO in the presence of methanolic solutions of sodium methoxide. When the reactions are carried out at room temperature η3-allylpalladium complexes are isolated, and their carbonylation gives β,γ-unsaturated esters.
SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME
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Page/Page column 92-93, (2019/11/19)
The present disclosure relates to 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, solid forms and polymorphs thereof, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the FGFR-associated or mediated diseases such as cancer.
Photocatalytic hydrodefluorination: Facile access to partially fluorinated aromatics
Senaweera, Sameera M.,Singh, Anuradha,Weaver, Jimmie D.
supporting information, p. 3002 - 3005 (2014/03/21)
Polyfluorinated aromatics are essential to materials science as well as the pharmaceutical and agrochemical industries and yet are often difficult to access. This Communication describes a photocatalytic hydrodefluorination approach which begins with easily accessible perfluoroarenes and selectively reduces the C-F bonds. The method allows facile access to a number of partially fluorinated arenes and takes place with unprecedented catalytic activity using a safe and inexpensive amine as the reductant.