2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide

Base Information

Chemical Name:2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide
CAS No.:1429385-25-0
Molecular Formula:C₁₆H₁₄Cl₃NO₂
Molecular Weight:358.652
Hs Code.:

Synonyms:2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide

Chemical Property:

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Technology Process of 2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide

There total 9 articles about 2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429382-53-5
(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

: 79-04-9
chloroacetyl chloride

: 1429385-25-0
2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: rac-(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

: 1429385-25-0
2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In tetrahydrofuran;
DOI:10.1021/jm401767k

Reference yield:

: 622-95-7
4-chlorobenzyl bromide

: 1429385-25-0
2-chloro-N-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver(I) nitrite / diethyl ether / 16 h / 0 °C / Inert atmosphere; Darkness

2.1: aluminum oxide; pyridine / Inert atmosphere; Darkness

3.1: hydrogenchloride; zinc / water / Inert atmosphere

4.1: sodium hydroxide / Inert atmosphere

4.2: Inert atmosphere; Reflux

5.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

With pyridine; hydrogenchloride; aluminum oxide; silver(I) nitrite; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; diethyl ether; water;
DOI:10.1021/jm401767k