N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

Base Information

• Chemical Name: N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide
• CAS No.: 1448316-87-7
• Molecular Formula: C₂₉H₂₈F₅N₅O₂S
• Molecular Weight: 605.632

Synonyms:N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

Chemical Property of N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

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Technology Process of N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

There total 12 articles about N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

methyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetate (1448316-85-5) + methylmagnesium bromide (75-16-1) → N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ6-sulphanyl)benzamide (1448316-87-7)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Cooling with ice; Inert atmosphere;

Reference yield:

nicotinoylacetonitrile (30510-18-0) → N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ6-sulphanyl)benzamide (1448316-87-7)

Guidance literature:

Multi-step reaction with 7 steps

1: hydrogenchloride / ethanol; water / 4 h / Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

3: sulfuric acid / ethanol / 0.25 h / 130 °C / Microwave irradiation

4: palladium 10% on activated carbon; ammonium formate / ethanol; water / 2.5 h / Reflux

5: HATU; dmap / N,N-dimethyl-formamide / 3 h / 20 °C

6: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

7: tetrahydrofuran / 0 - 20 °C / Cooling with ice; Inert atmosphere

With hydrogenchloride; dmap; sulfuric acid; palladium 10% on activated carbon; ammonium formate; palladium diacetate; caesium carbonate; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetate (1448316-83-3) → N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ6-sulphanyl)benzamide (1448316-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

2: tetrahydrofuran / 0 - 20 °C / Cooling with ice; Inert atmosphere

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane;

upstream raw materials:

tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate

methyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate

methylmagnesium bromide

nicotinoylacetonitrile

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