α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone

Base Information

Chemical Name:α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone
CAS No.:1354638-40-6
Molecular Formula:C₁₆H₂₄N₂O₅
Molecular Weight:324.377
Hs Code.:

Synonyms:α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone

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Chemical Property of α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone

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Technology Process of α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone

There total 5 articles about α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1354638-37-1
N-(4-formylbenzyl)butanamide

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 1354638-40-6
α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone

Guidance literature:: With acetic acid; zinc; In ethanol; at 0 - 60 ℃; Inert atmosphere; Molecular sieve; Darkness;
DOI:10.1021/jo202098x

Reference yield:

: 66739-89-7
4-(1,3-dioxolan-2-yl)benzonitrile

: 1354638-40-6
α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; acetic acid / 12 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

3: water; acetic acid

4: acetic acid; zinc / ethanol / 0 - 60 °C / Inert atmosphere; Molecular sieve; Darkness

With palladium 10% on activated carbon; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; dichloromethane; acetic acid;
DOI:10.1021/jo202098x

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1354638-40-6
α-(4-butanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene

2: palladium 10% on activated carbon; hydrogen / ethanol; acetic acid / 12 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

4: water; acetic acid

5: acetic acid; zinc / ethanol / 0 - 60 °C / Inert atmosphere; Molecular sieve; Darkness

With palladium 10% on activated carbon; water; hydrogen; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1021/jo202098x