Ranitidine HCL

Base Information

• Chemical Name: Ranitidine HCL
• CAS No.: 66357-59-3
• Molecular Formula: C₁₃H₂₂N₄O₃S*ClH
• Molecular Weight: 350.87
• Hs Code.: 2932190002
• European Community (EC) Number: 266-333-0
• Wikidata: Q27108147
• ChEMBL ID: CHEMBL1330865
• Mol file: 66357-59-3.mol

Synonyms:AH 19065;AH-19065;AH19065;Biotidin;Hydrochloride, Ranitidine;N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine;Ranisen;Ranitidin;Ranitidine;Ranitidine Hydrochloride;Sostril;Zantac;Zantic

Chemical Property of Ranitidine HCL

Chemical Property:

• Appearance/Colour: Off-white crystalline solid
• Melting Point: 134 °C (dec.)
• PSA: 111.56000
• LogP: 3.56600
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Sensitive.: Hygroscopic
• Solubility.: H2O: 1.8 mg/mL
• Water Solubility.: Soluble in water, 2-hydroxypropyl-beta-cyclodextrin, acetic acid, methanol, ethanol and dimethyl sulfoxide. Insoluble in chlorof
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 350.1179395
• Heavy Atom Count: 22
• Complexity: 347

Purity/Quality:

99.9% ^*data from raw suppliers

Ranitidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 20/21/22-39/23/24/25-23/24/25-11
• Safety Statements: 22-24/25-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Pharmaceuticals
• Canonical SMILES: CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.Cl
• Isomeric SMILES: CN/C(=C/[N+](=O)[O-])/NCCSCC1=CC=C(O1)CN(C)C.Cl
• Recent ClinicalTrials: Amphiregulin Versus Non-Amphiregulin Supplementation to Maturation Culturing Medium in IVM.
• Recent EU Clinical Trials: Estudio fase I/II de quimioterapia con la combinación de Pemetrexed y Cisplatino concomitante con radioterapia seguida de quimioterapia de consolidación con Pemetrexed en pacientes con cáncer de pulmón no microcítico localmente avanzado inoperable
• Recent NIPH Clinical Trials: The analysis of QOL in the patients of GERD with chronic liver disease after the treatment of PPI or H2-B
• Indications: For the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other high acid secretion disorders.
• Uses: A histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative. antifungal An H-2 histamine receptor antagonistRanitidine hydrochloride is mainly used as an H2-receptor antagonist and helps in the treatment of gastrointestinal lesions because of excessive gastric acid secretion. It also serves as an antiulcer drug.

Technology Process of Ranitidine HCL

There total 4 articles about Ranitidine HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.84%

Ranitidine (66357-35-5,70956-04-6) → ranitidine hydrochloride (66357-59-3,71130-06-8,358638-36-5)

Guidance literature:

With hydrogenchloride; In ethanol; at 0 ℃; pH=4.5 - 6.5; Temperature; pH-value;

Reference yield: 91.7%

ranitidine (66357-35-5,70956-04-6) → ranitidine hydrochloride (66357-35-5,66357-59-3,71130-06-8,358638-36-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; isopropyl alcohol; at 25 ℃; for 0.75h;

Reference yield:

2-methylamino-2-methylthio-1-nitroethene (102721-76-6,61832-41-5) + 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine (66356-53-4) → ranitidine hydrochloride (66357-59-3,71130-06-8,358638-36-5)

Guidance literature:

2-methylamino-2-methylthio-1-nitroethene; 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine; In water; at 38 ℃; for 7h; under 75.0075 - 225.023 Torr;

With hydrogenchloride; In ethanol; water; at 0 - 3 ℃; under 225.023 - 375.038 Torr; pH=6.3; Temperature;

upstream raw materials:

Ranitidine

2-methylamino-2-methylthio-1-nitroethene

5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine

ranitidine

Downstream raw materials:

(5-dimethylaminomethyl-furan-2-yl)-methanol

3-methylamino-5,6-dihydro-2H-thiazin-2-one O-5-dimethylaminomethylfurfuryloxime

3-methylamino-5,6-dihydro-2H-1,4-thiazin-2-one oxime hydrochloride

N,N-dimethyl-5-(2(1-methylamino-2-(5-dimethylaminomethyl-2-furfuryl)-2-nitrovinylamino)ethyl-thiomethyl)furfurylamine

Refernces

• 1、 -. "Preparation method of high-transmittance ranitidine hydrochloride". Paragraph 0014; 0015. . Retrieved 2017/12/27.
• 2、 -. "ANHYDROUS TABLET OF RANITIDINE HYDROCHLORIDE WITH DOUBLE-LAYER COATING AND ITS COMPOSITION". Page/Page column 7. . Retrieved 2008/06/13.