5,6-DIHYDRO-3-METHYLAMINO-2H-1,4-THIAZIN-2-ONE OXIME

Base Information

• Chemical Name: 5,6-DIHYDRO-3-METHYLAMINO-2H-1,4-THIAZIN-2-ONE OXIME
• CAS No.: 148639-72-9
• Molecular Formula: C₅H₉N₃OS
• Molecular Weight: 159.212
• Mol file: 148639-72-9.mol

Synonyms:5,6-DIHYDRO-3-METHYLAMINO-2H-1,4-THIAZIN-2-ONE OXIME;RANITIDINE IMPURITY G

Chemical Property of 5,6-DIHYDRO-3-METHYLAMINO-2H-1,4-THIAZIN-2-ONE OXIME

Chemical Property:

• Boiling Point: 313.9±25.0 °C(Predicted)
• PKA: 9.40±0.40(Predicted)
• PSA: 82.28000
• Density: 1.45±0.1 g/cm3(Predicted)
• LogP: -0.03470

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DIHYDRO-3-METHYLAMINO-2H-1,4-THIAZIN-2-ONE OXIME

There total 2 articles about 5,6-DIHYDRO-3-METHYLAMINO-2H-1,4-THIAZIN-2-ONE OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ranitidine hydrochloride (66357-59-3,71130-06-8,358638-36-5) → (5-dimethylaminomethyl-furan-2-yl)-methanol (15433-79-1) + 3-methylamino-5,6-dihydro-2H-1,4-thiazine-2-one oxime (148639-72-9) + 3-Methylamino-5,6-dihydro-[1,4]thiazin-2-one O-(5-dimethylaminomethyl-furan-2-ylmethyl)-oxime + C21H33N5O4

Guidance literature:

With water; at 65 ℃; pH 4.01; var. pHs and temp., also in solid-state;

DOI:10.1002/jps.2600820611

Reference yield:

2-(nitromethylene)thiazolidine (66357-40-2) + methylamine (74-89-5) → 2-<<1-(methylamino)-2-nitroethyl>amino>ethanethiol (66357-41-3) + 3-methylamino-5,6-dihydro-2H-1,4-thiazine-2-one oxime (148639-72-9)

Guidance literature:

In ethanol; Ambient temperature;

upstream raw materials:

ranitidine hydrochloride

2-(nitromethylene)thiazolidine

methylamine