(2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt

Base Information

Chemical Name:(2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt
CAS No.:1303582-20-8
Molecular Formula:C₂HF₃O₂*C₂₃H₂₀F₃N₃O₅
Molecular Weight:589.448
Hs Code.:

Synonyms:(2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt

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Chemical Property of (2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt

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Technology Process of (2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt

There total 8 articles about (2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1303587-91-8
(2-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methanone

: 76-05-1
trifluoroacetic acid

: 1303582-20-8
(2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃; for 1h;

Reference yield:

: 66572-56-3
2-bromoisonicotinic acid

: 1303582-20-8
(2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 1.5 h / 0 °C / Reflux

1.3: pH 2 - 3

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C

3.1: hydrogenchloride / water; methanol / 1 h / 20 °C

With hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 15128-82-2
3-hydroxy-2-nitropyridine

: 1303582-20-8
(2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate; bromine / methanol / 0.5 h / 0 °C

1.2: 0.17 h / 0 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: acetic acid; iron / 5 h / 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 90 °C

5.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 50 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C

7.1: hydrogenchloride / water; methanol / 1 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; bromine; sodium methylate; iron; potassium carbonate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;