(2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

Base Information

Chemical Name:(2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester
CAS No.:73397-34-9
Molecular Formula:C₄₀H₅₈N₄O₁₀
Molecular Weight:754.921
Hs Code.:

Synonyms:(2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

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Chemical Property of (2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

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Technology Process of (2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

There total 8 articles about (2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 73397-34-9
(2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / triethylamine / H₂O; dioxane / 25 °C

2: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; water;
DOI:10.1021/jo01300a004

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 73397-34-9
(2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / triethylamine, DCC, HOBt / CH₂Cl₂ / 5 °C

2: 1.) HCl, 2.) triethylamine, DCC, HOBt

3: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jo01300a004

Reference yield:

: 70853-26-8
(R)-4-methyl-1-oxopentane-2-benzylcarbamate

: 73397-34-9
(2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaHSO₃ / 1.) 5 deg C, overnight, 2.) ethyl acetate, water, room temp., 4 h

2: 90 percent / concentrated HCl / dioxane / 12 h / Heating

3: 73 percent / triethylamine / H₂O; dioxane / 25 °C

4: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride

With hydrogenchloride; benzotriazol-1-ol; sodium hydrogensulfite; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; water;
DOI:10.1021/jo01300a004