2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine

Base Information

Chemical Name:2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine
CAS No.:231626-96-3
Molecular Formula:C₄₁H₇₄N₄O₆Si₄
Molecular Weight:831.404
Hs Code.:

2-benzyloxymethyl-9-[3,4-bis-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9<i>H</i>-purine

Synonyms:2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine

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Chemical Property of 2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine

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Technology Process of 2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine

There total 6 articles about 2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 231626-95-2
2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one

: 231626-96-3
2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1055/s-1999-3104

Reference yield:

: 19810-31-2
Benzyloxyacetyl chloride

: 231626-96-3
2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂

2: 80 percent / DBU / toluene / 16 h / Heating

3: 81 percent / Ph₃P, DEAD / tetrahydrofuran

With 2,6-di-tert-butyl-4-methylpyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1055/s-1999-3104

Reference yield:

: 2627-69-2
AICA riboside

: 231626-96-3
2-benzyloxymethyl-9-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-trimethylsilanyl-ethoxy)-9H-purine

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / imidazole / dimethylformamide / 72 h / Ambient temperature

2: 63 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂

3: 80 percent / DBU / toluene / 16 h / Heating

4: 81 percent / Ph₃P, DEAD / tetrahydrofuran

With 1H-imidazole; 2,6-di-tert-butyl-4-methylpyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-1999-3104