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2627-69-2

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Product FOB Price Min.Order Supply Ability Supplier
Factory supply SARMS AICAR(Acadesine) 99% CAS 2627-69-2 in stock
Cas No: 2627-69-2
No Data 1 Gram 100 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
Acadesine (INN) AICAR AICA-riboside cas:2627-69-2
Cas No: 2627-69-2
USD $ 1.0-1.0 / Gram 5 Gram 1000 Kilogram/Week tonda chem-tech co.,ltd Contact Supplier
Acadesine
Cas No: 2627-69-2
USD $ 10.0-10.0 / Gram 1 Gram 10000 Kilogram/Day Zhejiang J&C Biological Technology Co.,Limited Contact Supplier
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Cas No: 2627-69-2
No Data No Data Metric Ton/Day Hubei God bull Pharmaceutical Co.,Ltd Contact Supplier
AICAR
Cas No: 2627-69-2
USD $ 1.0-1.5 / Gram 1 Gram 1-100 Metric Ton/Month Baowei Technology Qinhuangdao Co., Ltd Contact Supplier
AICAR
Cas No: 2627-69-2
No Data 1 Gram 100 Kilogram/Month Shanghai AngewChem Co., Ltd. Contact Supplier
High quality AICAR with best price 2627-69-2
Cas No: 2627-69-2
USD $ 1.0-1.0 / Kilogram 1 Kilogram 3000 Metric Ton/Month Qingdao Sigma Chemical Co., Ltd. Contact Supplier
Acadesine
Cas No: 2627-69-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
CAS: 2627-69-2 Acadesine factory sales
Cas No: 2627-69-2
No Data 1 Kilogram 100 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier
High purity Various Specifications Acadesine CAS:2627-69-2
Cas No: 2627-69-2
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier

2627-69-2 Usage

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

Uses

AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

Chemical Properties

Solid

Definition

ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.

adenosine regulating agents

Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate).
Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.

Uses

glucose uptake stimulant; AMPK activator
InChI:InChI=1/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1

2627-69-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (A9978)  AICAR  ≥98% (HPLC), powder 2627-69-2 A9978-25MG 2,302.56CNY Detail
Sigma (A9978)  AICAR  ≥98% (HPLC), powder 2627-69-2 A9978-5MG 671.58CNY Detail

2627-69-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name AICAR

1.2 Other means of identification

Product number -
Other names Acadesine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2627-69-2 SDS

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