methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate

Base Information

Chemical Name:methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate
CAS No.:162439-95-4
Molecular Formula:C₂₄H₂₂O₉
Molecular Weight:454.433
Hs Code.:

Synonyms:methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate

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Chemical Property of methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate

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Technology Process of methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate

There total 3 articles about methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 125803-65-8
methyl (E)-3-<2RS,3RS)-2-(4-acetoxy-3-methoxyphenyl)-2,3-dihydro-7-methoxy-3-(methoxycarbonyl)-1-benzofuran-5-yl>-2-propenoate

: 162439-95-4
methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 42h; Heating;
DOI:10.1248/cpb.42.2500

Reference yield: 50.0%

: 118799-80-7
(E)-methyl 3-<(2RS,3SR)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonyl-1-benzofuran-5-yl>-1-propenoate

: 108-24-7
acetic anhydride

: 162439-95-4
methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate

Guidance literature:: (E)-methyl 3-<(2RS,3SR)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonyl-1-benzofuran-5-yl>-1-propenoate; acetic anhydride; With pyridine; dmap; at 20 ℃; Inert atmosphere;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 84h; Inert atmosphere; Reflux;
DOI:10.1021/acs.joc.1c00348

Reference yield:

: 118799-80-7
(E)-methyl 3-<(2RS,3SR)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonyl-1-benzofuran-5-yl>-1-propenoate

: 162439-95-4
methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-(N,N-dimethylamino)pyridine; pyridine

2: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / dioxane

With pyridine; dmap; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane;
DOI:10.1016/j.bmc.2004.10.058