trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane

Base Information

Chemical Name:trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane
CAS No.:1338448-91-1
Molecular Formula:C₁₉H₂₇ClF₂O
Molecular Weight:344.873
Hs Code.:

Synonyms:trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane

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Chemical Property of trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane

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Technology Process of trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane

There total 13 articles about trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

: 1338448-90-0
trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

: 1338448-91-1
trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane

Guidance literature:: trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane; With pyridine; In toluene; at 45 ℃; for 1h; Inert atmosphere;

With thionyl chloride; In toluene; at 45 - 55 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1338448-90-0
trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

: 1338448-91-1
trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane

: 1338446-34-6
1-butoxy-4-(trans-4-(trans-4-((trans-4-(2,3-difluoro-4-(hexyloxy)phenyl)cyclohexyl)methoxy)-2,3-difluorophenyl)cyclohexyl)-2,3-difluorobenzene

Guidance literature:: With pyridine; thionyl chloride; sodium hydrogencarbonate; In water; toluene;

Reference yield:

: C₂₃H₃₂F₂O₃

: 1338448-91-1
trans-4-(4-hexyloxy-2,3-difluorophenyl)-chloromethylcyclohexane

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -30 - -20 °C / Reflux

1.2: 0.5 h / -30 - -10 °C

2.1: formic acid / toluene / 2 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - -10 °C

4.1: pyridine / toluene / 1 h / 45 °C / Inert atmosphere

4.2: 2 h / 45 - 55 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; formic acid; potassium tert-butylate; In tetrahydrofuran; toluene;