trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

Base Information

Chemical Name:trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane
CAS No.:1338448-90-0
Molecular Formula:C₁₉H₂₈F₂O₂
Molecular Weight:326.427
Hs Code.:

Synonyms:trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

Suppliers and Price of trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

There total 10 articles about trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.6%

: 1277641-44-7
trans-4-(4-hexyloxy-2,3-difluorophenyl)-cyclohexanecarbaldehyde

: 1338448-90-0
trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 - -10 ℃; for 2h;

Reference yield:

: C₂₃H₃₂F₂O₃

: 1338448-90-0
trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -30 - -20 °C / Reflux

1.2: 0.5 h / -30 - -10 °C

2.1: formic acid / toluene / 2 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - -10 °C

With lithium aluminium tetrahydride; formic acid; potassium tert-butylate; In tetrahydrofuran; toluene;

Reference yield:

: 136239-66-2
2,3-difluorophenyl butyl ether

: 1338448-90-0
trans-4-(4-hexyloxy-2,3-difluorophenyl)-hydroxymethylcyclohexane

Guidance literature:: Multi-step reaction with 11 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane; hexane / 2 h / -74 - -70 °C / Inert atmosphere

1.2: 8 h / -75 - -70 °C / Inert atmosphere

1.3: 2 h / Reflux

2.1: sec.-butyllithium / tetrahydrofuran / 2 h / -74 - -70 °C / Inert atmosphere

2.2: 8 h / -74 - -65 °C / Inert atmosphere

2.3: 2 h / 25 - 30 °C / Inert atmosphere

3.1: sec.-butyllithium / tetrahydrofuran; cyclohexane; hexane / 2 h / -74 - -70 °C / Inert atmosphere

3.2: 8 h / -75 - -70 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

4.2: 20 °C

5.1: formic acid / toluene / 2 h / Reflux

6.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -30 - -10 °C / Inert atmosphere

6.2: 2 h / Inert atmosphere; Reflux

7.1: formic acid / toluene / 2 h / Reflux

8.1: Oxone / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

9.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -30 - -20 °C / Reflux

9.2: 0.5 h / -30 - -10 °C

10.1: formic acid / toluene / 2 h / Reflux

11.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - -10 °C

With Oxone; lithium aluminium tetrahydride; formic acid; potassium tert-butylate; sec.-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; cyclohexane; N,N-dimethyl-formamide; toluene;