N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide
• CAS No.: 1075178-41-4
• Molecular Formula: C₁₁H₁₁BrF₃NO₂
• Molecular Weight: 326.113
• Mol file: 1075178-41-4.mol

Synonyms:N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide

Chemical Property of N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide

There total 4 articles about N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl trifluoroacetate, (383-63-1) + (±)-3-amino-1-(3-bromophenyl)propan-1-ol (1075178-40-3) → N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide (1075178-41-4)

Guidance literature:

In tert-butyl methyl ether; at 0 - 20 ℃; for 0.95h;

Reference yield: 60.0%

ethyl trifluoroacetate, (383-63-1) + (±)-3-amino-1-(3-bromophenyl)propan-1-ol (1075178-40-3) → N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide (1075178-41-4) + 2,2,2-trifluoro-N-(3-hydroxy-3-phenylpropyl)acetamide (1075178-42-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide (1075178-41-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.58 h / -50 °C

1.2: -50 - 0 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.2: 0.5 h

3.1: ethanol

With dimethylsulfide borane complex; potassium tert-butylate; In tetrahydrofuran; ethanol;

upstream raw materials:

ethyl trifluoroacetate,

(±)-3-amino-1-(3-bromophenyl)propan-1-ol

m-bromobenzoic aldehyde

3-(3-bromophenyl)-3-hydroxypropanenitrile

Downstream raw materials:

C₁₁H₉BrF₃NO₂

2,2,2-trifluoro-N-(3-hydroxy-3-(3-(3-methoxyprop-1-ynyl)phenyl)propyl)acetamide

2,2,2-trifiuoro-N-(3-hydroxy-3-(3-(3-hydroxy-3-propylhex-1-ynyl)phenyl)propyl)acetamide