(R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Base Information

Chemical Name:(R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one
CAS No.:1397683-39-4
Molecular Formula:C₁₃H₁₂BrN₃O
Molecular Weight:306.162
Hs Code.:

Synonyms:(R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Suppliers and Price of (R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

There total 8 articles about (R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (R)-2-[2-amino-2-(3-bromo-phenyl)-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester trifluoroacetic acid

: 1397683-39-4
(R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: (R)-2-[2-amino-2-(3-bromo-phenyl)-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester trifluoroacetic acid; With potassium carbonate; In ethanol; at 20 - 90 ℃; for 5h;

With hydrogenchloride; In water;

Reference yield:

: 1183581-39-6
(RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester

: 1397683-39-4
(R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

1.2: 20 °C

2.1: Chiralpak_.(R). Daicel AD / carbon dioxide; isopropylamine; methanol

3.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

3.2: pH 1 - 2 / Cooling with ice

4.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

4.2: 64 h / 20 °C

5.1: sodium periodate / ruthenium trichloride / acetonitrile; water / 2 h / 0 - 20 °C

6.1: caesium carbonate / dimethyl sulfoxide / 3.5 h / 20 - 110 °C

6.2: 2 h

7.1: dichloromethane / 2 h / 0 - 20 °C

8.1: potassium carbonate / ethanol / 5 h / 20 - 90 °C

With sodium periodate; lithium aluminium tetrahydride; thionyl chloride; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; ruthenium trichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; water; dimethyl sulfoxide; isopropylamine; acetonitrile;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1397683-39-4
(R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.2: 20 °C

4.1: Chiralpak_.(R). Daicel AD / carbon dioxide; isopropylamine; methanol

5.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

5.2: pH 1 - 2 / Cooling with ice

6.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

6.2: 64 h / 20 °C

7.1: sodium periodate / ruthenium trichloride / acetonitrile; water / 2 h / 0 - 20 °C

8.1: caesium carbonate / dimethyl sulfoxide / 3.5 h / 20 - 110 °C

8.2: 2 h

9.1: dichloromethane / 2 h / 0 - 20 °C

10.1: potassium carbonate / ethanol / 5 h / 20 - 90 °C

With hydrogenchloride; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; caesium carbonate; ruthenium trichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; ammonia; water; dimethyl sulfoxide; isopropylamine; acetonitrile;