3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde

Base Information

Chemical Name:3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde
CAS No.:1049810-37-8
Molecular Formula:C₂₉H₃₁ClN₄O₄S
Molecular Weight:567.109
Hs Code.:

Synonyms:3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde

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Chemical Property of 3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde

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Technology Process of 3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde

There total 9 articles about 3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1048035-13-7
3-(4-Chloro-3-iodo-phenyl)-5-methanesulfonyl-1-(3-morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

: 77123-55-8
3-((trimethylsilyl)ethynyl)benzaldehyde

: 1049810-37-8
3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In water; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1048674-89-0
3-(4-Chloro-3-iodo-phenyl)-1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

: 1049810-37-8
3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / acetone / 5 h / 55 °C

2.1: acetic acid / dichloromethane / 0.17 h

2.2: 60 h

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / water; N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; water; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1049102-99-9
C₁₀H₁₈N₂O₃S

: 1049810-37-8
3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

1.2: 14 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 48 h

3.1: hydrogenchloride; water / acetone / 5 h / 55 °C

4.1: acetic acid / dichloromethane / 0.17 h

4.2: 60 h

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / water; N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; water; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; water; N,N-dimethyl-formamide; acetone;