1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine

Base Information

Chemical Name:1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine
CAS No.:1049810-38-9
Molecular Formula:C₃₅H₄₄ClN₅O₄S
Molecular Weight:666.284
Hs Code.:

1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine

Synonyms:1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine

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Chemical Property of 1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine

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Technology Process of 1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine

There total 10 articles about 1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 130290-79-8
4-tetrahydropyranmethylamine

: 1049810-37-8
3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde

: 1049810-38-9
1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine

Guidance literature:: 4-tetrahydropyranmethylamine; 3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)benzaldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 16h;

Reference yield:

: 1048035-13-7
3-(4-Chloro-3-iodo-phenyl)-5-methanesulfonyl-1-(3-morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

: 1049810-38-9
1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / water; N,N-dimethyl-formamide / 18 h / 20 °C

2.1: acetic acid / dichloromethane / 0.5 h / 20 °C

2.2: 16 h

With acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1048674-89-0
3-(4-Chloro-3-iodo-phenyl)-1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

: 1049810-38-9
1-[3-({2-chloro-5-[5-(methylsulfonyl)-1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)methanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / acetone / 5 h / 55 °C

2.1: acetic acid / dichloromethane / 0.17 h

2.2: 60 h

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / water; N,N-dimethyl-formamide / 18 h / 20 °C

4.1: acetic acid / dichloromethane / 0.5 h / 20 °C

4.2: 16 h

With hydrogenchloride; water; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; water; N,N-dimethyl-formamide; acetone;