ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate

Base Information

• Chemical Name: ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate
• CAS No.: 1420880-46-1
• Molecular Formula: C₂₆H₂₃N₃O₃
• Molecular Weight: 429.455

Synonyms:ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate

Chemical Property of ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate

Chemical Property:

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Technology Process of ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate

There total 8 articles about ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

orthocarbonic acid tetraethyl ester (78-09-1) + ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)benzoate (1420880-45-0) → ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate (1420880-46-1)

Guidance literature:

With acetic acid; In methanol; at 80 ℃; for 2h;

DOI:10.1002/jlcr.2956

Reference yield:

ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)-3-nitrobenzoate (1420880-44-9) → ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate (1420880-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; tin(II) chloride hydrate / 2.5 h / Cooling with ice

2: acetic acid / methanol / 2 h / 80 °C

With hydrogenchloride; tin(II) chloride hydrate; acetic acid; In methanol;

DOI:10.1002/jlcr.2956

Reference yield:

2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-carbonitrile (1420880-42-7) → ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate (1420880-46-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 7 h / Reflux

2: hydrogenchloride / methanol; ethyl acetate / 2 h / 20 °C

3: hydrogenchloride; tin(II) chloride hydrate / 2.5 h / Cooling with ice

4: acetic acid / methanol / 2 h / 80 °C

With hydrogenchloride; tin(II) chloride hydrate; potassium carbonate; acetic acid; In methanol; ethyl acetate; acetonitrile;

DOI:10.1002/jlcr.2956

upstream raw materials:

2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-carbonitrile

ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate

ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

orthocarbonic acid tetraethyl ester

Downstream raw materials:

C₂₄H₁₆⁽²⁾H₄N₆O₃

ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo [d]imidazole-7-carboxylate

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