78-09-1Relevant articles and documents
Method for efficiently rectifying and producing tetraethyl orthocarbonate
-
Paragraph 0023-0028; 0029-0034; 0035-0040; 0041-0046, (2018/04/02)
The invention relates to the field of refining chemicals and specifically relates to a method for efficiently rectifying and producing tetraethyl orthocarbonate. According to the method, a low-polarity inert solvent is used for treating tetraethyl orthocarbonate, so that the extracting function is achieved, less water can be co-boiled and brought away in a rectifying process and the product is prevented from degrading in the rectifying process; the solid alkali is added, so that the pH value of the rectifying system is increased and the product is prevented from continuously degrading under the effect of pH value decreasing in the rectifying process; the technical measure is adopted for acquiring the efficiently rectified and stably produced high-purity tetraethyl orthocarbonate. Comparedwith the present technology, the method provided by the invention has the characteristics of high efficiency, stability, and the like, the high-purity product can be continuously rectified and separated and the purity of the product can reach up to 99.5% or above.
Mechanistic study of the ring-size modulation in Michael-Dieckmann type reactions of 2-acylaminoacrylates with ketene diethyl acetal
Avenoza, Alberto,Busto, Jesus H.,Canal, Noelia,Garcia, Jose I.,Jimenez-Oses, Gonzalo,Peregrina, Jesus M.,Perez-Fernandez, Marta
, p. 224 - 229 (2008/02/02)
An unexpected modulation of the chemoselectivity in the Michael-Dieckmann type reactions of 2-acylaminoacrylates with ketene diethyl acetal is observed, depending on the nature of the acylamino group. Experimental and theoretical studies are presented to offer insights into the origin of this substituent effect in terms of a polar stepwise mechanism. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
CRYSTAL AND PROCESS FOR PRODUCING THE SAME
-
Page 18, (2010/02/06)
A process for producing crystals of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.