2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide

Base Information

• Chemical Name: 2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide
• CAS No.: 1228377-61-4
• Molecular Formula: C₃₃H₃₆N₅O₉P
• Molecular Weight: 677.651
• Mol file: 1228377-61-4.mol

Synonyms:2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide

Chemical Property of 2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide

There total 2 articles about 2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

naphthalene-1-yl-L-phenylalanine benzyloxy ester phosphorochloridate (874362-24-0) + C13H18N4O5 (139620-91-0) → 2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide (1228377-61-4)

Guidance literature:

C₁₃H₁₈N₄O₅; With tert-butylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

naphthalene-1-yl-L-phenylalanine benzyloxy ester phosphorochloridate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2010.02.015

Reference yield: 32.0%

1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate (906670-24-4) + C13H18N4O5 (139620-91-0) → 2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide (1228377-61-4)

Guidance literature:

C₁₃H₁₈N₄O₅; With tert-butylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2010.02.015

Reference yield: 28.0%

2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide (1228377-61-4) → ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphate (1228377-64-7)

Guidance literature:

With formic acid; water; at 20 ℃;

DOI:10.1016/j.bmc.2010.02.015

upstream raw materials:

1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate

C₁₃H₁₈N₄O₅

naphthalene-1-yl-L-phenylalanine benzyloxy ester phosphorochloridate

Downstream raw materials:

ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphate