874362-24-0

Upstream product

• 31651-76-0 1-naphthyl dichlorophosphate 
• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 
• 90-15-3 α-naphthol 
• 962-39-0 L-Phenylalanine benzyl ester 

Downstream Products

• 1228377-61-4 2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxy-L-alaninyl)] phosphoramide 
• 1228377-63-6 2',3'-O,O-cyclopentylidene-ribavirin-5'-[1-naphthyl(benzyloxyglycinyl)] phosphoramide 
• 1338052-47-3 5-fluoro-2'-deoxyuridine-5'-O-[1-naphthyl(benzoxy-L-phenylalaninyl)]phosphate 

Relevant academic research and scientific papers

Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin

Ribavirin is a nucleoside analogue with broad antiviral activity. Here we report the synthesis and biological evaluation of novel ribavirin ProTides designed to deliver the bioactive ribavirin monophosphate into cells. Some of the compounds display activity similar to the parent nucleoside against a range of viruses. Enzymatic, cell lysate and preliminary modeling studies have been performed to investigate the lack of enhancement of potency by the ProTides, and these indicate a failure at the final, amino acid cleavage step in the ProTide activation process, leading to inefficient release of the nucleoside monophosphate.

Novel potential anticancer naphthyl phosphoramidates of BVdU: Separation of diastereoisomers and assignment of the absolute configuration of the phosphorus center

We have previously reported our SAR optimization of the anticancer agent thymectacin. Tuning of the parent ProTide structure initially involved the amino acid and, subsequently, the aromatic masking group on the phosphate moiety. Herein, derivatives beari