2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione

Base Information

Chemical Name:2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione
CAS No.:1075249-33-0
Molecular Formula:C₃₁H₂₅ClN₆O₂
Molecular Weight:549.031
Hs Code.:

Synonyms:2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione

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Chemical Property of 2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione

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Technology Process of 2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione

There total 2 articles about 2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1075249-37-4
tert-butyl (3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate

: 1075249-12-5
2-(4-bromophenyl)-1-(4-chlorophenyl)-7-ethyl-9-phenyl-1H-purine-6,8(7H,9H)-dione

: 1075249-33-0
2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione

Guidance literature:: tert-butyl (3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate; 2-(4-bromophenyl)-1-(4-chlorophenyl)-7-ethyl-9-phenyl-1H-purine-6,8(7H,9H)-dione; With sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 100 ℃; for 3h;

With trifluoroacetic acid; In dichloromethane; for 6h;

Reference yield:

: 748812-61-5
(5-bromo-3-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester

: 1075249-33-0
2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2.5 h / 100 °C

2.1: sodium hydroxide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 3 h / 100 °C

2.2: 6 h

With sodium hydroxide; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;