Boc-6-Amino-5-methylpyridine-3-boronic acid pinacol ester

Base Information

• Chemical Name: Boc-6-Amino-5-methylpyridine-3-boronic acid pinacol ester
• CAS No.: 1075249-37-4
• Molecular Formula: C17H27BN2O4
• Molecular Weight: 334.223
• Hs Code.: 2934999090
• Mol file: 1075249-37-4.mol

Synonyms:Boc-6-Amino-5-methylpyridine-3-boronic acid pinacol ester;tert-butyl 3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbaMate;tert-butyl N-[3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate;tert-Butyl 2-((3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)amino)acet;tert-Butyl 2-((3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)amino)acetate

Chemical Property of Boc-6-Amino-5-methylpyridine-3-boronic acid pinacol ester

Chemical Property:

• PSA: 69.68000
• LogP: 2.51580
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl2-((3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)amino)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-6-Amino-5-methylpyridine-3-boronic acid pinacol ester

There total 1 articles about Boc-6-Amino-5-methylpyridine-3-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(pinacol)diborane (73183-34-3) + (5-bromo-3-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester (748812-61-5) → tert-butyl (3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (1075249-37-4)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 2.5h;

Reference yield:

tert-butyl (3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (1075249-37-4) + 2-(4-bromophenyl)-1-(4-chlorophenyl)-7-ethyl-9-phenyl-1H-purine-6,8(7H,9H)-dione (1075249-12-5) → 2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione (1075249-33-0)

Guidance literature:

tert-butyl (3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate; 2-(4-bromophenyl)-1-(4-chlorophenyl)-7-ethyl-9-phenyl-1H-purine-6,8(7H,9H)-dione; With sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 100 ℃; for 3h;

With trifluoroacetic acid; In dichloromethane; for 6h;

upstream raw materials:

bis(pinacol)diborane

(5-bromo-3-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester

Downstream raw materials:

2-[4-(6-amino-5-methyl-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-7-ethyl-9-phenyl-7,9-dihydro-1H-purine-6,8-dione

Refernces