Technology Process of N-(6-benzoyl-2,3-dimethylphenyl)-2,2,2-trifluoroacetamide
There total 8 articles about N-(6-benzoyl-2,3-dimethylphenyl)-2,2,2-trifluoroacetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7,8-dimethyl-2-(trifluoromethyl)-4H-3,1-benzooxazin-4-one; phenylmagnesium bromide;
In
tetrahydrofuran; diethyl ether;
at -15 - 20 ℃;
for 3.5h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; diethyl ether; water;
Cooling with ice;
DOI:10.1002/hlca.201200490
- Guidance literature:
-
With
aluminum (III) chloride;
In
benzene;
at 90 ℃;
for 3h;
Cooling with ice;
DOI:10.1002/hlca.201200490
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; sodium thiosulfate pentahydrate; hydroxylamine sulfate / water / 45 - 75 °C
1.2: 75 °C
2.1: sodium hydroxide; dihydrogen peroxide / water / 0 °C
3.1: 1.25 h / 20 °C
4.1: diethyl ether; tetrahydrofuran / 3.5 h / -15 - 20 °C / Inert atmosphere
4.2: Cooling with ice
With
hydrogenchloride; sodium thiosulfate pentahydrate; dihydrogen peroxide; hydroxylamine sulfate; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; water;
DOI:10.1002/hlca.201200490
