2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide

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Chemical Name:2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide
CAS No.:1192720-23-2
Molecular Formula:C₃₁H₃₃N₅O₂
Molecular Weight:507.635
Hs Code.:

Synonyms:2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide

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Chemical Property of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide

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Technology Process of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide

There total 12 articles about 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1192719-19-9
(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-oxo-acetyl chloride

: 1029805-00-2
4-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-phenyl amine

: 1192720-23-2
2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide

Guidance literature:: With triethylamine; In dichloromethane; for 1.25h;

Reference yield:

: 30838-93-8
2-chloro-4,6-dimethyl-pyridine

: 1192720-23-2
2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylene glycol dimethyl ether / 36.5 h / 160 °C

2.1: potassium carbonate / diethylene glycol dimethyl ether / 0.25 h / 20 °C

2.2: 46.25 h / Reflux

2.3: 1 h

3.1: ammonium hydroxide / water / pH ~ 9

4.1: hydrogen / nickel / methanol / 36 h / 4654.46 Torr

5.1: triethylamine / dichloromethane / 1.25 h

With ammonium hydroxide; hydrogen; potassium carbonate; triethylamine; nickel; In methanol; dichloromethane; diethylene glycol dimethyl ether; water;

Reference yield:

: 163613-83-0
1-(4,6-dimethyl-pyridin-2-yl)-piperazine

: 1192720-23-2
2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(4,6-dimethylpyridin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / diethylene glycol dimethyl ether / 0.25 h / 20 °C

1.2: 46.25 h / Reflux

1.3: 1 h

2.1: ammonium hydroxide / water / pH ~ 9

3.1: hydrogen / nickel / methanol / 36 h / 4654.46 Torr

4.1: triethylamine / dichloromethane / 1.25 h

With ammonium hydroxide; hydrogen; potassium carbonate; triethylamine; nickel; In methanol; dichloromethane; diethylene glycol dimethyl ether; water;