Piperazine, 1-(4,6-dimethyl-2-pyridinyl)- (9CI)

Base Information

• Chemical Name: Piperazine, 1-(4,6-dimethyl-2-pyridinyl)- (9CI)
• CAS No.: 163613-83-0
• Molecular Formula: C11H17 N3
• Molecular Weight: 191.276
• Hs Code.: 2933990090
• Mol file: 163613-83-0.mol

Synonyms:1-(4,6-Dimethyl-2-pyridyl)piperazine;1-(4,6-Dimethylpyridin-2-yl)piperazine; 4,6-Dimethyl-2-(piperazin-1-yl)pyridine

Chemical Property of Piperazine, 1-(4,6-dimethyl-2-pyridinyl)- (9CI)

Chemical Property:

• Boiling Point: 362.6±42.0 °C(Predicted)
• PKA: 9.79±0.27(Predicted)
• PSA: 28.16000
• Density: 1.042±0.06 g/cm3(Predicted)
• LogP: 2.30380

Purity/Quality:

97% ^*data from raw suppliers

1-(4,6-Dimethylpyridin-2-yl)piperazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazine, 1-(4,6-dimethyl-2-pyridinyl)- (9CI)

There total 2 articles about Piperazine, 1-(4,6-dimethyl-2-pyridinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

piperazine (110-85-0) + 2-chloro-4,6-dimethyl-pyridine (30838-93-8) → 1-(4,6-dimethyl-pyridin-2-yl)-piperazine (163613-83-0)

Guidance literature:

In diethylene glycol dimethyl ether; at 160 ℃; for 36.5h;

Reference yield:

2-Amino-4,6-dimethylpyridine (5407-87-4) → 1-(4,6-dimethyl-pyridin-2-yl)-piperazine (163613-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 °C

1.2: 0.5 h

2.1: dimethyl sulfoxide / 24 h / 140 °C

With hydrogenchloride; sodium nitrite; In water; dimethyl sulfoxide;

Reference yield: 55.0%

1-(4,6-dimethyl-pyridin-2-yl)-piperazine (163613-83-0) + 4-chlorobenzonitrile (100-00-5) → 1-(4,6-dimethyl-pyridin-2-yl)-4-(4-nitro-phenyl)-piperazine (1029804-04-3)

Guidance literature:

With potassium carbonate; In diethylene glycol dimethyl ether; for 16h; Reflux;

upstream raw materials:

piperazine

2-chloro-4,6-dimethyl-pyridine

2-Amino-4,6-dimethylpyridine

Downstream raw materials:

1-(4,6-dimethyl-pyridin-2-yl)-4-(4-nitro-phenyl)-piperazine

1-(4,6-dimethyl-pyridin-2-yl)-4-(3-methyl-4-nitro-phenyl)-piperazine

1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine

1-(4,6-dimethyl-pyridin-2-yl)-4-(2-methyl-4-nitro-phenyl)-piperazine