3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene

Base Information

Chemical Name:3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene
CAS No.:897672-25-2
Molecular Formula:C₂₄H₃₅BrO₇S
Molecular Weight:547.508
Hs Code.:

Synonyms:3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene

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Chemical Property of 3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene

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Technology Process of 3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene

There total 5 articles about 3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.8%

: 897672-24-1
p-iodo-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}benzene

: 29421-73-6
3,5-dibromo-2-methylthiophene

: 897672-25-2
3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene

Guidance literature:: p-iodo-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With boric acid tributyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

3,5-dibromo-2-methylthiophene; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; for 16h; Heating;
DOI:10.1021/jo060505t

Reference yield:

: 112-35-6,95507-80-5
triethylene glucol monomethyl ether

: 897672-25-2
3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / aq. NaOH / tetrahydrofuran

2.1: 90 percent / aq. KOH

3.1: 72 percent / aq. NaOH / tetrahydrofuran

4.1: 100 percent / K₂CO₃ / dimethylformamide / 7 h / 70 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: boric acid tri-n-butyl ester / tetrahydrofuran; hexane / 1 h / -78 °C

5.3: 69.8 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran; hexane / 16 h / Heating

With potassium hydroxide; sodium hydroxide; n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo060505t

Reference yield:

: 23601-40-3,95507-80-5
hexaethylene glycol monomethyl ether

: 897672-25-2
3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 72 percent / aq. NaOH / tetrahydrofuran

2.1: 100 percent / K₂CO₃ / dimethylformamide / 7 h / 70 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: boric acid tri-n-butyl ester / tetrahydrofuran; hexane / 1 h / -78 °C

3.3: 69.8 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran; hexane / 16 h / Heating

With sodium hydroxide; n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo060505t