2,5,8,11,14,17-Hexaoxanonadecan-19-ol

Base Information

• Chemical Name: 2,5,8,11,14,17-Hexaoxanonadecan-19-ol
• CAS No.: 23601-40-3
• Molecular Formula: C13H28O7
• Molecular Weight: 296.361
• Hs Code.: 29094990
• European Community (EC) Number: 245-775-8
• DSSTox Substance ID: DTXSID9066914
• Nikkaji Number: J97.013A
• Wikidata: Q27120577
• Metabolomics Workbench ID: 56580
• Mol file: 23601-40-3.mol

Synonyms:23601-40-3;Hexaethylene glycol monomethyl ether;2,5,8,11,14,17-Hexaoxanonadecan-19-ol;m-PEG6-alcohol;mPEG6-OH;hexaethyleneglycolmonomethylether;Hexaethyleneglycol monomethyl ether;3,6,9,12,15,18-Hexaoxanonadecan-1-ol;2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol;C13H28O7;EINECS 245-775-8;MFCD00045996;mPEG6-Alcohol;Methyl-PEG6-alcohol;SCHEMBL144769;DTXSID9066914;CHEBI:44752;BCP11261;AKOS022173510;C13-H28-O7;DS-7473;HY-W042625;BP-22069;SY038327;CS-0035628;FT-0638341;H0808;H10936;J-521437;Q27120577;Hexaethylene glycol monomethyl ether 2,5,8,11,14,17-Hexaoxanonadecan-19-ol

Chemical Property of 2,5,8,11,14,17-Hexaoxanonadecan-19-ol

Chemical Property:

• Refractive Index: 1.4510-1.4550
• Boiling Point: 375.6 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 180.9 °C
• PSA: 75.61000
• Density: 1.062g/cm³
• LogP: -0.29190
• Storage Temp.: -20°C
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 17
• Exact Mass: 296.18350323
• Heavy Atom Count: 20
• Complexity: 169

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hexaethylene Glycol Monomethyl Ether >97.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCOCCOCCOCCOCCO
• Description: m-PEG6-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
• Uses: Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Technology Process of 2,5,8,11,14,17-Hexaoxanonadecan-19-ol

There total 24 articles about 2,5,8,11,14,17-Hexaoxanonadecan-19-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

hexaethylene glycol monobenzyl monomethyl ether (125562-28-9) → hexaethylene glycol monomethyl ether (23601-40-3,95507-80-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; for 1.5h;

Reference yield: 90.0%

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → hexaethylene glycol monomethyl ether (23601-40-3,95507-80-5)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/jo060505t

Reference yield: 89.5%

pentaethylene glycol (2615-15-8) + methyl iodide (74-88-4) → hexaethylene glycol monomethyl ether (23601-40-3,95507-80-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;

DOI:10.1021/jacs.8b02066

upstream raw materials:

triethylene glucol monomethyl ether

oxirane

2-methoxy-ethanol

1-chloro-3,6,9-trioxadecane

Downstream raw materials:

2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

1-Phenyl-2,5,8,11,14,17,20,23,26,29-decaoxatriacontane

3,6,9,12,15,18,21,24,27,30,33-undecaoxatetratriacontanoic acid

O-methyl-decaethylene glycol

Refernces

• 1、 Stone, Matthew T.,Moore, Jeffrey S.. "A Water-Soluble m-Phenylene Ethynylene Foldamer". . p. 469 - 472. Retrieved 2004.
• 2、 Deng, Tao,Mao, Xianglan,Xiao, Yan,Yang, Zhigang,Zheng, Xing,Jiang, Zhong-Xing. "Monodisperse oligoethylene glycols modified Camptothecin, 10-Hydroxycamptothecin and SN38 prodrugs". supporting information. p. 581 - 584. Retrieved 2019/01/04.
• 3、 Graham, Ben,Fayter, Alice E. R.,Houston, Judith E.,Evans, Rachel C.,Gibson, Matthew I.. "Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization". supporting information. p. 5682 - 5685. Retrieved 2018/05/09.