2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide

Base Information

Chemical Name:2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide
CAS No.:1384426-40-7
Molecular Formula:C₁₇H₂₀ClN₃O
Molecular Weight:317.818
Hs Code.:

Synonyms:2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide

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Chemical Property of 2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide

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Technology Process of 2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide

There total 2 articles about 2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1384426-35-0
6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-ol

: 107-14-2
chloroacetonitrile

: 1384426-40-7
2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide

Guidance literature:: With sulfuric acid; acetic acid; at 60 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tet.2012.05.074

Reference yield:

: 43102-70-1
6,6-dimethyl-1-phenyl-1,5,6,7-tetrahydro-4H-indazol-4-one

: 1384426-40-7
2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 12 h / 20 °C / Inert atmosphere

2: sulfuric acid; acetic acid / 24 h / 60 °C / Inert atmosphere

With sodium tetrahydroborate; sulfuric acid; acetic acid; In ethanol; 2: Ritter reaction;
DOI:10.1016/j.tet.2012.05.074

Reference yield: 80.0%

: 1384426-40-7
2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide

: 104-15-4
toluene-4-sulfonic acid

: 1384426-71-4
(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)ammonium toluene-4-sulfonate

Guidance literature:: 2-chloro-N-(6,6-dimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide; With thiourea; In ethanol; for 23h; Inert atmosphere; Reflux;

With sodium hydroxide; In water; ethyl acetate; pH=10;

toluene-4-sulfonic acid; In ethyl acetate; at 20 ℃;
DOI:10.1016/j.tet.2012.05.074