(3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

Base Information

Chemical Name:(3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone
CAS No.:1254035-99-8
Molecular Formula:C₁₃H₁₃N₃O₄
Molecular Weight:275.264
Hs Code.:

Synonyms:(3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

Suppliers and Price of (3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

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Technology Process of (3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

There total 1 articles about (3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 18621-18-6
azetion-3-ol hydrochloride

: 99367-44-9
ethyl 5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylate

: 1254035-99-8
(3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: With sodium cyanide; triethylamine; In methanol; at 20 ℃;

Reference yield: 77.0%

: 1254035-99-8
(3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

: 124-63-0
methanesulfonyl chloride

: 1254036-00-4
1-(5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/acs.jmedchem.5b01654

Reference yield:

: 1254035-99-8
(3-hydroxyazetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

: (5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)(3-(4-((methyl((3-methyloxetan-3-yl)methyl)amino)methyl)phenoxy)azetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl acetamide / 110 °C

3: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 20 °C / Cooling with ice

4: triethylamine / dichloromethane / 0.5 h

With sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/acs.jmedchem.5b01654