3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one

Base Information

Chemical Name:3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one
CAS No.:1601475-53-9
Molecular Formula:C₂₄H₃₂O₂S
Molecular Weight:384.583
Hs Code.:

Synonyms:3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one

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Chemical Property of 3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one

Chemical Property:

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Technology Process of 3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one

There total 6 articles about 3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1601475-50-6
3'-(4-(4-methoxyphenyl)butyl)spiro[adamantane-2,2'-thietan]-4'-one

: 74-88-4
methyl iodide

: 1601475-53-9
3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -40 ℃; for 3h;
DOI:10.1021/jo500577c

Reference yield:

: C₂₇H₄₀O₃S

: 1601475-53-9
3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3,4,5,6-pentafluorophenol / dichloromethane / 5 h / 0 °C

3: lithium diisopropyl amide / tetrahydrofuran / 3 h / -78 - -40 °C

With 2,3,4,5,6-pentafluorophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo500577c

Reference yield:

: 1601475-45-9
tert-butyl 6-(4-methoxyphenyl)hexanoate

: 1601475-53-9
3'-(4-(4-methoxyphenyl)butyl)-3'-methylspiro[adamantane-2,2'-thietan]-4'-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexane / 0.67 h / -78 °C

1.2: 2 h / -78 - 0 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3,4,5,6-pentafluorophenol / dichloromethane / 5 h / 0 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -78 - -40 °C

With 2,3,4,5,6-pentafluorophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1021/jo500577c