2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one>

Base Information

• Chemical Name: 2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one>
• CAS No.: 74982-37-9
• Molecular Formula: C₂₀H₂₂N₄O₅S
• Molecular Weight: 430.484

Synonyms:2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one>

Chemical Property of 2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one>

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Technology Process of 2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one>

There total 2 articles about 2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

N-<(4-amino-2-methylpyrimidin-5-yl)methyl>-N-<1-(2-oxido-1,2-oxathiolan-3-ylidene)ethyl>-(2-methoxyphenyl)oxalamide (66666-34-0) → 2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one> (74982-37-9)

Guidance literature:

In acetic acid; for 48h;

DOI:10.1248/cpb.28.769

Reference yield: 7.0%

4-(4-amino-2-methylpyrimidin-5-yl)methyl-6-(2-hydroxyethyl)-2-(2-methoxyphenyl)-5-methyl-2,3-dihydro-4H-1,4-thiazin-3-one (7692-38-8) → 2-Methoxybenzoic acid (579-75-9) + 2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one> (74982-37-9) + N-<(4-amino-2-methylpyrimidin-5-yl)methyl>-N-<1-(2-oxido-1,2-oxathiolan-3-ylidene)ethyl>-(2-methoxyphenyl)oxalamide (66666-34-0)

Guidance literature:

With dihydrogen peroxide; In acetic acid; for 56h; Ambient temperature;

DOI:10.1248/cpb.28.769

Reference yield: 70.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-hydroxy-2'-methylene-4'-(2-methoxyphenyl)-tetrahydropyrrol-5'-one> (74982-37-9) → 2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-methoxy-2'-methylene-4'-(2-methoxyphenyl)tetrahydropyrrol-5'-one> (74982-40-4)

Guidance literature:

In methanol; diethyl ether; chloroform; for 4h;

DOI:10.1248/cpb.28.769

upstream raw materials:

4-(4-amino-2-methylpyrimidin-5-yl)methyl-6-(2-hydroxyethyl)-2-(2-methoxyphenyl)-5-methyl-2,3-dihydro-4H-1,4-thiazin-3-one

N-<(4-amino-2-methylpyrimidin-5-yl)methyl>-N-<1-(2-oxido-1,2-oxathiolan-3-ylidene)ethyl>-(2-methoxyphenyl)oxalamide

Downstream raw materials:

2-oxido-1,2-oxathiolane-3-spiro-3'-<1'-(4-amino-2-methylpyrimidin-5-yl)methyl-4'-methoxy-2'-methylene-4'-(2-methoxyphenyl)tetrahydropyrrol-5'-one>

2-aza-2-(4-amino-2-methylpyrimidin-5-yl)methyl-4-hydroxy-4-(2-methoxyphenyl)-1-methyl-8-oxabicyclo<3.3.0>octan-3-one

2-aza-2-(4-amino-2-methylpyrimidin-5-yl)methyl-4-hydroxy-4-(2-methoxyphenyl)-1-methyl-8-oxabicyclo<3.3.0>octan-3-one

1-(4-amino-2-methylpyrimidin-5-yl)methyl-4-hydroxy-3-(2-hydroxyethyl)-4-(2-methoxyphenyl)-2-methyl-Δ²-pyrrolin-5-one

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